Comic strip by Chris Ware, from the building stories collection.

The sense of scale here tells a lot. In the first two frames, the size of the building from frame one to frame two gets larger, letting the reader know that the individual is moving. As the character moves through the panels, they take up more and more of the panel until they look almost right at the reader, and disappear. The story that’s implied here is that they’re going somewhere they might not want the reader to follow. If we read the text, we see a very pessimistic view of their situation. The weather is turning, they’re slowly heading in a direction, and then they just stop appearing in the strip. The city, which in other frames was small and in the background, is now level in the last panel, implying that there’s a shift in perspective. We’re no longer looking over the shoulder of the character, we’re overlooking a city block, as if to say we may have misplaced the character. It’s daunting, it’s depressing, and it’s a really good way to end this comic.